Early Administration of Nelonemdaz May Improve the Stroke Outcomes in Patients With Acute Stroke
A phase III clinical trial did not demonstrate a significant impact of nelonemdaz on patients with acute ischemic stroke. 1 Although not prespecified in the original protocol, post-hoc analyses sug-gested potential interactions between treatment effects and time-related metrics, leading us to hypothesize that earlier drug administration may yield better outcomes.This study aimed to determine the treatment effect of nelonemdaz when administered early after emergency room (ER) arrival.
Authors
- Kyu Sun Yum
- Hee-Kwon Park
- Seong Hwan Ahn (ORCID: https://orcid.org/0000-0002-4778-491X)
- Heejung Mo (ORCID: https://orcid.org/0000-0001-7810-035X)
- Sungwook Yu (ORCID: https://orcid.org/0000-0002-4224-4025)
- Young Seo Kim
- Ji Sung Lee (ORCID: https://orcid.org/0000-0001-8194-3462)
- Jun Young Chang (ORCID: https://orcid.org/0000-0003-4880-9258)
- Jinkwon Kim (ORCID: https://orcid.org/0000-0003-0156-9736)
- Man‐Seok Park (ORCID: https://orcid.org/0000-0002-0637-5394)
- Keun‐Hwa Jung (ORCID: https://orcid.org/0000-0003-1433-8005)
- Jae Guk Kim (ORCID: https://orcid.org/0000-0002-2446-4497)
- Moo‐Seok Park (ORCID: https://orcid.org/0000-0002-2779-095X)
- Chang‐Hun Kim (ORCID: https://orcid.org/0000-0002-9630-9031)
- Hyun Goo Kang (ORCID: https://orcid.org/0000-0001-5443-3635)
- Joonsang Yoo (ORCID: https://orcid.org/0000-0003-1169-6798)
- Dennis W. Choi (ORCID: https://orcid.org/0000-0002-4493-488X)
- Sung‐Il Sohn (ORCID: https://orcid.org/0000-0002-6900-1242)
- Jae‐Kwan Cha (ORCID: https://orcid.org/0000-0002-1049-5196)
- Sung Hyuk Heo (ORCID: https://orcid.org/0000-0002-9215-5119)
- Dong‐Ick Shin (ORCID: https://orcid.org/0000-0001-5770-0268)
- Jay Chol Choi (ORCID: https://orcid.org/0000-0002-3550-2196)
- Eung Gyu Kim (ORCID: https://orcid.org/0000-0002-3305-4668)
- Sun U. Kwon (ORCID: https://orcid.org/0000-0001-8302-331X)
- Ji Man Hong (ORCID: https://orcid.org/0000-0001-6803-1207)
- Yeong‐Bae Lee (ORCID: https://orcid.org/0000-0001-5952-1423)
- Yang‐Ha Hwang (ORCID: https://orcid.org/0000-0002-6665-7481)
- Soo-Kyoung Kim (ORCID: https://orcid.org/0000-0003-0994-8503)
- Jin Soo Lee (ORCID: https://orcid.org/0000-0002-7225-6166)
- Jung Hwa Seo (ORCID: https://orcid.org/0000-0003-0207-2772)
- Hee‐Joon Bae
- Tae Jin Song
- Byoung Joo Gwag
- Jee Hyun Kwon
- Chun San An
- Woo Keun Seo
Institutions
- Ulsan College (KR)
- Gachon University (KR)
- Ewha Womans University (KR)
- Yonsei University (KR)
- Eulji University (KR)
- Severance Hospital (KR)
- Dong-A University Hospital (KR)
- Kyungpook National University Hospital (KR)
- Asan Medical Center (KR)
- Samsung Medical Center (KR)
- Seoul National University Hospital (KR)
- Seoul National University Bundang Hospital (KR)
- Kyung Hee University (KR)
- University of Ulsan (KR)
- Gyeongsang National University Hospital (KR)
- Chonnam National University Hospital (KR)
- Chosun University Hospital (KR)
- Inje University Busan Paik Hospital (KR)
- Jeonbuk National University Hospital (KR)
- Ulsan University Hospital (KR)
- Inha University Hospital (KR)
- Chungbuk National University Hospital (KR)
- Korea University (JP)
- Jeju National University Hospital (KR)
- Keimyung University (KR)
- Ajou University (KR)
- Stony Brook University (US)
- Wonkwang University (KR)
- Sungkyunkwan University (KR)
Publication Details
- Journal
- Journal of Stroke
- Published
- 2025-05-30
- DOI
- https://doi.org/10.5853/jos.2024.05113
- Citations
- 2
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 2.71