Assessing Causality Between Endocrine, Nutritional, and Metabolic Disease and Pulmonary Tuberculosis: A Mendelian Randomization Study
This MR study provides novel genetic evidence that ENMD significantly elevates PTB risk. Notably, high cholesterol, BMI, and LDL-c exhibit protective effects against PTB at the genetic level in European ancestry, while T2DM shows no causal association. These findings highlight the complex role of metabolic factors in tuberculosis susceptibility and suggest potential biological mechanisms linking metabolic dysregulation to PTB pathogenesis.
Authors
- Yan Gao (ORCID: https://orcid.org/0000-0003-2876-5550)
- Qiming Zhang (ORCID: https://orcid.org/0009-0007-7202-5740)
- Jinwen Su
- Zhi Chen (ORCID: https://orcid.org/0000-0001-9328-349X)
- Chunxia Zhang (ORCID: https://orcid.org/0000-0003-0063-9181)
- Yiguo Wang (ORCID: https://orcid.org/0000-0003-1458-9234)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Health Science Reports
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1002/hsr2.70875
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00