Drug Release Kinetics and Comparative Study of Oxaprozin Nonogel with Market Formulation

The proposed work was aimed to Drug release kinetics and comparative studies of a nanotechnology-based formulation of oxaprozin nanogel. In this prepared and optimized formulation of F-7 nanogel formulation performed the drug release kinetic studies with model dependent strategies depend on various numerical functions, which depict the release profile. When an appropriate capacity has been chosen, the release profiles are assessed relying upon the determined model boundaries. The information acquired from ex vivo permeation studies were plotted in various models of data treatment and compared with market formulation Ibugic gel manufactured by Cipla pharmaceutical Ltd. Data observed as drug release kinetics studies in each situation, R2 value was determined from the chart and detailed. Zero order release kinetics was found (R2=0.992) to fit the release data best and the % drug release for optimized up to 17 hours of F-7 formulation was found 95.89% which was higher than the market formulation nanogel 92.31% up to same time duration 17 hours. Keywords: Oxaprozin, Nanogel, Drug release kinetics, comparative study and hydrogel.