Development and Evaluation of Antifungal Drug Product by Solid Dispersion Technique using Drug Coating and Seal Coating Approach (Itraconazole Capsules 100 mg)

Itraconazole Capsules 100 mg were formulated utilizing the Solid Dispersion Technique with Drug Coating and Seal Coating Approach in order to make the formulation as economical as possible. The formulation comprised of Sugar Spheres as base pellets, Hypromellose 5 cps as Solubility enhancing carrier, Poloxamer 188 (Lutrol F 68) as Solubilizer, Absolute Ethanol and Methylene chloride as solvent, Polyethylene Glycol 20,000 as Solubilizer, Talc and Colloidal Silicon Dioxide as Glidant. The improved formulation's in-vitro dissolution research revealed 100% release at 90 minutes, whereas the RLD formulation demonstrated 95% release. The formulation of Itraconazole Capsules 100 mg employing the solid dispersion technique with drug coating and seal coating approach has resulted in a stable and economical formulation, according to this finding.