Phytochemical Screening, Characterization and Formulation and Evaluation of Herbal Gel of Abelmoschus Manihot for Atopic Dermatitis

Atopic dermatitis is skin disease that is commonly known as eczema that causes dry, itchy and inflamed skin it is irritating disease but cannot spread from one person to another through direct or indirect contact. Literature review also reveals treatment of Atopic Dermatitis (AD) have been reported for the extracts and active compounds from A. manihot both in vitro and in vivo. From the MIC concentration has been proved the ethanolic extract was in-vitro potential for Atropic dermatitis activity, Isolated compound is positively to the Salkowski’s test and Lieberman-Burchard test for steroids and triterpenes. Evaluation of formulated gel by different parameters have been done Physiochemical parameters like appearance, consistency and homogeneity were determined by visual inspection. In vitro diffusion study carried out in diffusion cell for 4 hr showed HG III with maximum drug release (87.25 %) as compared to the other gel formulations. Ex-vivo permeability and retention studies done In terms of drug penetration, both th systems were showing almost comparable results; however retention was higher with HG-II gel compared to the HG-III gel.