Enhancement of Solubility of Anti-Inflammatory Drug by Using Different Solubility Enhancement Techniques

Using a range of pure solvents and solvent mixes, this study investigated the solubility enhancement of four cox-2 inhibitors: celecoxib, rofecoxib, meloxicam, and nimesulide. The solvents included water, alcohols, glycols, glycerol, and polyethylene glycol 400 (PEG 400). The combined solvent systems included water-ethanol, glycerol- ethanol, and polyethylene glycol-ethanol. Using 0.05M glycine-sodium hydroxide buffer solutions, a pH-solubility profile of the medications was acquired in the pH range of 7.0 to 19.9. It was discovered that PEG 400, higher glycols, and lower alcohols made effective solvents for these medications. Using ethanol as the second solvent could greatly increase the water solubility of celecoxib, rofecoxib, and nimesulide. The PEG 400-ethanol system had the highest potential for solubilisation among the mixed solvent systems. Meloxicam and nimesulide showed a considerable increase in solubility when the pH value rose. Drug dissolution by pure solvents was shown to be primarily influenced by the solvent's physico-chemical characteristics, including polarity, intermolecular interactions, and the solvent's capacity to establish a hydrogen bond with the drug molecules. The solubilisation power increased with the degree of polarity difference between the two solvents in a particular mixed solution. Nevertheless, the solubilisation power in a particular mixed solvent solution could not be connected to the medicines' polarity. This study has also addressed the significance of the solubility data with regard to formulation development.