Dichapetalin-type triterpenoids inhibits macrophage interferon expression by regulating the cGas-STING pathway, suggesting potential application in immunosuppression
Taken together, this study suggests that DTs isolated from the <i>Dichapetalum longipetalum</i> (Turcz.) Engl. inhibits macrophage activation through the cGas-STING pathway in MPMs, which would be potential for the treatment of autoimmune diseases.
Authors
- Yue Wang (ORCID: https://orcid.org/0000-0003-3263-6794)
- Long Li (ORCID: https://orcid.org/0000-0002-4727-9307)
- Guorong Li (ORCID: https://orcid.org/0000-0002-9439-4754)
- Sheng‐An Tang (ORCID: https://orcid.org/0000-0001-8473-0972)
- Yiming Sun
- Chuan Zhao
- Yurong Da
Institutions
- Theranostics (New Zealand) (NZ)
- Institute of Immunology (HR)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Immunopharmacology and Immunotoxicology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1080/08923973.2025.2513476
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00