Exosomes containing long non-coding RNA AGAP2-AS1 promote the differentiation of CD4+ T cells through the miR-424-5p/SGK1 axis in psoriasis
Psoriatic HaCaTs deliver AGAP2-AS1 to CD4<sup>+</sup> T cells via exosomes, inducing Th1 and Th17 differentiation through the miR-424-5p/SGK1 axis, thereby promoting the progression of psoriasis. These findings provide novel insights into the pathogenesis of psoriasis and potential therapeutic targets.
Authors
- Chenglai Xia (ORCID: https://orcid.org/0000-0002-4528-7960)
- Xue Zeng (ORCID: https://orcid.org/0000-0002-6064-5340)
- Xuebiao Peng (ORCID: https://orcid.org/0000-0002-8490-2831)
- Xiwei Zhang (ORCID: https://orcid.org/0000-0001-7496-6666)
- Ziqi Yuan
Institutions
- Foshan Maternity and Child Health Care Hospital (CN)
- Nanfang Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fgene.2025.1521470
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Natural Science Foundation of Guangdong Province