Linoleic acid metabolite 13-Hydroxyoctadecadienoic acid as a biphasic ferroptosis modulator in granulosa cells: multi-omics analysis of ovine atretic follicles
In contrast, high-dose 13(S)-HODE induces labile iron accumulation through activation of transferrin receptor and ferritin heavy chain 1, enhancing ferroptosis sensitivity in granulosa cells. These findings provide insights into the molecular mechanisms regulating follicle development and offer potential therapeutic targets for enhanced follicular development and improved reproductive outcomes.
Authors
- Dengke Zeng
- Junlan Wang (ORCID: https://orcid.org/0000-0002-6262-2484)
- Erhan Hai (ORCID: https://orcid.org/0009-0003-0385-1898)
- Lixia He (ORCID: https://orcid.org/0000-0003-3954-1966)
- Nan Zhang (ORCID: https://orcid.org/0009-0001-6336-7534)
- Jiaxin Zhang (ORCID: https://orcid.org/0000-0003-4566-7987)
- Ning Zhang (ORCID: https://orcid.org/0000-0002-1559-111X)
- Yukun Song (ORCID: https://orcid.org/0000-0001-5827-4598)
- Yan Sun (ORCID: https://orcid.org/0000-0003-0706-1204)
Institutions
- Inner Mongolia Agricultural University (CN)
- Inner Mongolia University (CN)
- Ministry of Agriculture and Rural Affairs (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fcell.2025.1610621
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00