ATP/P2X7 receptor/NLRP3 pathway facilitates renal tubular epithelial-myofibroblast transdifferentiation and interstitial fibrosis in rats with unilateral ureteral obstruction
The ATP/P2X7R/NLRP3 pathway is involved in renal TEMT and interstitial fibrosis. P2X7R antagonists attenuate renal interstitial fibrosis and may potentially be used as effective therapeutic agents.
Authors
- Feiyan Li
- Hui Zhuan Tan (ORCID: https://orcid.org/0000-0003-4899-6399)
- Quanfeng Deng (ORCID: https://orcid.org/0000-0003-0407-9812)
- Yan Cui (ORCID: https://orcid.org/0000-0002-5940-2886)
- Ziwen Li (ORCID: https://orcid.org/0000-0002-2466-9388)
- Shiqiang Yan (ORCID: https://orcid.org/0000-0002-6046-7652)
Institutions
- Chengdu Medical College (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- First Affiliated Hospital of Chengdu Medical College (CN)
- Northwest A&F University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fphar.2025.1598151
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00