Voiding symptom severity varies independently from non-adrenergic prostate smooth muscle contractions in patients undergoing surgery for benign prostatic hyperplasia
Symptom severity increases with α<sub>1</sub>-adrenergic, but not with non-adrenergic contractions in patients undergoing surgery for BPH. Endothelin-1-induced contractions are similar to noradrenaline-induced contractions. Conditions necessitating BPH surgery may not necessarily depend on α<sub>1</sub>-adrenergic tone, but may involve non-adrenergic contractions or factors beyond contraction.
Authors
- Laurenz Berger
- Martin Hennenberg (ORCID: https://orcid.org/0000-0003-1305-6727)
- Patrick Keller (ORCID: https://orcid.org/0000-0002-1565-1258)
- Philipp Weinhold (ORCID: https://orcid.org/0000-0002-9144-9289)
- Christian Georg Stief (ORCID: https://orcid.org/0000-0003-3291-9460)
- Alexander Tamalunas
- Sheng Hu (ORCID: https://orcid.org/0000-0002-5565-7072)
- P. Nicola
Institutions
- LMU Klinikum (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fphys.2025.1612954
- Citations
- 2
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 3.67