Reference-free deconvolution of complex samples based on cross-cell-type differential analysis: Systematic evaluations with various feature selection options

Comprehensive simulation studies and analyses of seven real datasets show the excellent performance of the proposed method. The proposed method, that is, reference-free deconvolution based on cross-cell-type differential (RFdecd), is implemented as an R package at https://github.com/wwzhang-study/RFdecd.