Impact of body composition on pathological response to neoadjuvant immunotherapy in dMMR/MSI-H colorectal cancer
Higher visceral adipose tissue volume is associated with improved pathological complete response in dMMR/MSI-H colorectal cancer patients treated with PD-1 inhibitors. However, this favorable effect of visceral adiposity may be diminished or reversed in elderly patients (≥ 65 y), highlighting the potential influence of aging on the metabolic-immune interplay in immunotherapy response.
Authors
- Weili Zhang (ORCID: https://orcid.org/0000-0003-4703-3486)
- Chuanmiao Xie (ORCID: https://orcid.org/0000-0001-8533-623X)
- Jian Zhou (ORCID: https://orcid.org/0000-0002-0749-1354)
- Zhenhai Lu (ORCID: https://orcid.org/0000-0003-3694-0830)
- Cheng Feng (ORCID: https://orcid.org/0000-0002-8785-2681)
- Ziyang Zeng (ORCID: https://orcid.org/0000-0003-0725-142X)
- Yuan Li (ORCID: https://orcid.org/0000-0002-3171-8053)
- Hao Wang (ORCID: https://orcid.org/0000-0001-7594-7387)
- Jianhong Peng (ORCID: https://orcid.org/0000-0002-0769-8195)
- E-er-man-bie-ke Jin-si-han (ORCID: https://orcid.org/0009-0005-1573-188X)
- Shaopu Lian
- Zhizhong Pan (ORCID: https://orcid.org/0000-0002-5198-2919)
Institutions
- Sun Yat-sen University (CN)
- Shenzhen University (CN)
- ShenZhen People’s Hospital (CN)
- Southern Medical University Shenzhen Hospital (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fimmu.2025.1589869
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05