Steamed panax notoginseng mitigates CA-MRSA USA300-induced necroptosis in human neutrophils
S-PN alleviates CA-MRSA infection-induced immune damage through dual mechanisms: suppression of bacterial virulence factors (PSM and PVL) and inhibition of PMNs necroptosis. These findings underscore its potential as a complementary therapeutic strategy against CA-MRSA infections, providing a theoretical foundation for integrating TCM into adjuvant treatments for drug-resistant bacterial infections.
Authors
- Cheng Chang Lu (ORCID: https://orcid.org/0000-0002-6474-9198)
- Weifeng Yang (ORCID: https://orcid.org/0000-0002-9339-1746)
- Bo Wen (ORCID: https://orcid.org/0000-0002-8337-220X)
- Haoran Zheng (ORCID: https://orcid.org/0000-0001-8558-7979)
- Xiaoyu Feng (ORCID: https://orcid.org/0000-0002-3203-8682)
- Chunyan Jiang (ORCID: https://orcid.org/0000-0001-8757-6229)
- H. An (ORCID: https://orcid.org/0009-0009-0857-8687)
- Lulu Zhang (ORCID: https://orcid.org/0000-0001-6065-3669)
- Yong Tan (ORCID: https://orcid.org/0000-0002-8655-5132)
- Yihuan Chen (ORCID: https://orcid.org/0000-0003-1898-6982)
- Yuwen Xia
- Yung‐Chi Cheng
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Yale University (US)
- Beijing Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fphar.2025.1546652
- Primary Topic
- Cell death mechanisms and regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Academy of Chinese Medical Sciences