Alteration in gut microbiota accompanied by increased intestinal permeability and Tfh/Tfr imbalance in patients with active SLE
Zonulin may be involved in the Tfh/Tfr immune imbalance in patients with SLE, and Faecalibacterium and Ruminococcus may contribute to disease development by regulating Treg cells and Tfh/Tfr imbalance. Taken together, these findings may provide new insights into the role of cytokines in the treatment of SLE.
Authors
- Xuehui Chu
- Yueying Wang (ORCID: https://orcid.org/0000-0002-2819-5888)
- Qian Xing (ORCID: https://orcid.org/0009-0001-8761-6005)
- Yuanyuan Han (ORCID: https://orcid.org/0000-0002-8843-6073)
- Shuya Li (ORCID: https://orcid.org/0000-0002-7263-0365)
- Nana Zhao (ORCID: https://orcid.org/0009-0000-6355-5597)
- Dazhen Guo
Institutions
- Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fcimb.2025.1565416
- Citations
- 5
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 4.03