Modified ZhuJing pill protects retinal pigment epithelium against oxidative stress-induced epithelial–mesenchymal transition through Nrf2-mediated Akt/GSK3β pathway
Our study suggested that RPE protection by mZJP against oxidative stress induced EMT through Nrf2 activation and inhibition of the Akt/GSK3β pathway. MZJP could be a potential candidate drug for the treatment of dry AMD.
Authors
- Xin-Rong Xu (ORCID: https://orcid.org/0000-0003-2047-7298)
- Mengqi Gao (ORCID: https://orcid.org/0000-0002-1428-891X)
- Xin Zhou (ORCID: https://orcid.org/0000-0002-6566-9018)
- Caijian Xiong
- Ning Yang (ORCID: https://orcid.org/0000-0002-6014-9670)
- Siqi Feng (ORCID: https://orcid.org/0000-0002-7535-2364)
- Qinyi Hui
- Yan Shao (ORCID: https://orcid.org/0000-0003-1188-0237)
- Qingzi Jin
- Siqi Zhou (ORCID: https://orcid.org/0009-0006-8916-1573)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Liuyang City Maternal and Child Health Hospital (CN)
- Anyang Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fphar.2025.1545731
- Citations
- 2
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 2.30
Funders
- National Natural Science Foundation of China