Adult-onset hypothyroidism induces granulosa cell apoptosis and affects ovarian follicle development in rats
In conclusion, adult-onset hypothyroidism interferes with normal follicle development and impairs fertility by promoting apoptosis in granulosa cells of antral follicles and inducing oxidative stress in oocytes.
Authors
- Wanqiong Li (ORCID: https://orcid.org/0009-0009-9994-1815)
- Jinfeng Xue (ORCID: https://orcid.org/0000-0003-1901-3912)
- Lingbin Qi
- Jiaying Qin
- Yazhong Ji (ORCID: https://orcid.org/0000-0002-4395-0378)
- Lina Zhang (ORCID: https://orcid.org/0000-0002-7747-7363)
- Zhigang Xue (ORCID: https://orcid.org/0009-0000-9022-8727)
- Xi Xiao (ORCID: https://orcid.org/0009-0000-0931-6982)
- Shuyue Li (ORCID: https://orcid.org/0009-0000-5839-1233)
Institutions
- Tongji University (CN)
- Tongji Hospital (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fcell.2025.1610694
- Citations
- 2
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 6.99