Network-based analysis and experimental validation of identified natural compounds from Yinchen Wuling San for acute myeloid leukemia
YWLS compounds, particularly Genkwanin, exhibit significant anti-leukemic activity via apoptosis induction, cell cycle modulation, and promote T cells proliferation. Genkwanin emerges as a promising therapeutic candidate for AML, warranting further clinical investigation.
Authors
- Xin Wang (ORCID: https://orcid.org/0000-0003-3209-5713)
- Xuelei Hu
- Biyu Zhang (ORCID: https://orcid.org/0000-0003-2437-8043)
- Denggang Fu (ORCID: https://orcid.org/0000-0003-0779-7975)
Institutions
- Jiujiang University (CN)
- Medical University of South Carolina (US)
- Wuhan Institute of Technology (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fphar.2025.1591164
- Citations
- 3
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 2.42