Ovarian ROS-dependent IgG accumulation precedes lipofuscin deposition and follicular decline: comparative insights from the bitch and mouse models of ovarian aging
This study indicates that IgG deposition is an early event that precedes and possibly triggers the recruitment of macrophages. These findings provide new insights into mechanisms of ovarian aging and the use of antioxidants as a strategy to mitigate it.
Authors
- Luís Montenegro (ORCID: https://orcid.org/0000-0003-2737-1437)
- Henrique Almeida (ORCID: https://orcid.org/0000-0002-3036-3211)
- Ana Martins‐Bessa (ORCID: https://orcid.org/0000-0002-9566-3100)
- Luís Cardoso (ORCID: https://orcid.org/0000-0001-9833-7960)
- Anabela Pinto
- Catarina Brandão (ORCID: https://orcid.org/0000-0002-4305-5605)
- Elisabete Silva (ORCID: https://orcid.org/0000-0002-6736-3469)
- Inês Borges (ORCID: https://orcid.org/0000-0001-7444-7049)
- Hugo Carvalho
- Natália Rigos
Institutions
- University of Trás-os-Montes and Alto Douro (PT)
- Universidade do Porto (PT)
- Universidade Politécnica de Lisboa (PT)
- Hospital Pedro Hispano (PT)
- CUF Porto Hospital (PT)
- Associação Brasileira de Oncologia Veterinária (BR)
- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto (PT)
- Universidade Lusófona (PT)
Publication Details
- Journal
- Frontiers in Aging
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fragi.2025.1567909
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação para a Ciência e a Tecnologia