FimC binds to the promoter region of agn43 to modulate autoaggregation
This study demonstrated that <i>fimC</i> acts as an atypical DNA-binding protein to regulate the transcription of <i>agn43</i>. It also highlights the importance of <i>fimC</i> in the biofilm formation and adhesion ability of APEC, which provides new insights into the functions of the fimbrial chaperone protein <i>FimC</i>.
Authors
- Xiangpeng Niu
- Lingcong Kong (ORCID: https://orcid.org/0000-0002-1405-163X)
- Xiangan Han (ORCID: https://orcid.org/0000-0001-5625-637X)
- Wei Jie Jiang (ORCID: https://orcid.org/0000-0002-5473-0223)
- Ningyuan Zhong (ORCID: https://orcid.org/0000-0002-8667-8730)
- Yuanyuan Liu (ORCID: https://orcid.org/0000-0001-9865-1378)
- Zhihao Wang (ORCID: https://orcid.org/0000-0003-1561-4040)
- Saqib Nawaz (ORCID: https://orcid.org/0000-0002-9617-3074)
- Jian Tu
- Haiyang Zhang (ORCID: https://orcid.org/0009-0008-5896-1070)
Institutions
- Anhui Agricultural University (CN)
- Shanghai Veterinary Research Institute (CN)
- Hisense (China) (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fcimb.2025.1591206
- Primary Topic
- Bacterial Genetics and Biotechnology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China
- Science and Technology Commission of Shanghai Municipality