Single-cell transcriptome profiling reveals dynamic cell populations and immune infiltration in cerebral cavernous malformation
This study provides the single-cell transcriptomic analysis of CCM lesions, revealing increased monocytes, neutrophils, and NK cells, along with dysregulated gene expression and signaling pathways. Enhanced intercellular communication, particularly via VEGF and ADGRE5 pathways, highlights potential therapeutic targets for CCM.
Authors
- Shihao He (ORCID: https://orcid.org/0000-0002-2522-8656)
- Zhiguang Han (ORCID: https://orcid.org/0000-0002-8477-4227)
- Yuanli Zhao (ORCID: https://orcid.org/0000-0002-3263-6797)
- Yutong Liu (ORCID: https://orcid.org/0000-0002-0966-9646)
- Chunyan Lei (ORCID: https://orcid.org/0000-0003-4024-0896)
- Zhenyu Zhou (ORCID: https://orcid.org/0000-0002-5905-2150)
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Beijing Tian Tan Hospital (CN)
- First Hospital of Qinhuangdao (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fimmu.2025.1592343
- Citations
- 2
- Primary Topic
- Vascular Malformations Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- Peking Union Medical College Hospital