Integrative single-cell and cell-free plasma RNA transcriptomics identifies biomarkers for early non-invasive AD screening
This multi-omics approach overcomes limitations of invasive brain biomarkers and noisy blood-based signatures. The 34-gene panel provides non-invasive molecular insights into AD pathogenesis and early screening. While cfRNA stability challenges clinical translation, our framework highlights the potential for precision diagnostics and personalized therapeutic monitoring in AD.
Authors
- Renxin Zhang
- Yichao Wang (ORCID: https://orcid.org/0000-0001-7053-8269)
- Shao‐Xing Dai (ORCID: https://orcid.org/0000-0002-6919-2034)
- Li Wu (ORCID: https://orcid.org/0000-0001-9200-9376)
- Naixue Yang (ORCID: https://orcid.org/0000-0002-0705-7611)
Institutions
- Kunming University of Science and Technology (CN)
- Yunnan Yingmao Biotechnology (China) (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fnagi.2025.1571783
- Citations
- 1
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.81