From genomics to treatment: overcoming pan-drug-resistant Klebsiella pneumoniae in clinical settings
Dissection of the roles of the substitutions present in blaSHV-231 revealed that this variant was responsible for the reduced susceptibility to aztreonam-avibactam, at the expense of a higher susceptibility to clavulanate. Targeted therapy can be successful upon dissection of unexpected mechanisms of resistance that enhance the contribution of endemic β-lactamase.
Authors
- Fernando Pasterán (ORCID: https://orcid.org/0000-0001-5840-5869)
- Ezequiel Albornoz
- Melina Rapoport (ORCID: https://orcid.org/0000-0001-6961-640X)
- Mabel Rizzo
- Marcelo Radisic (ORCID: https://orcid.org/0000-0002-7459-6156)
- Gina Dotta (ORCID: https://orcid.org/0000-0003-1023-1606)
- Denise De Belder (ORCID: https://orcid.org/0000-0002-5568-4804)
- Alejandro J. Vila (ORCID: https://orcid.org/0000-0002-7978-3233)
- Paola Ceriana
- Juan Manuel de Mendieta
- Sonia Gómez (ORCID: https://orcid.org/0000-0001-9106-1762)
- Natalia Pujato
- Celeste Lucero (ORCID: https://orcid.org/0000-0003-3890-8930)
- María Alejandra Menocal
- Lucía Maccari
- Alejandra Fernández
- Lisandro J. González
- Alejandra Corso
Institutions
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Universidad de Buenos Aires (AR)
- National University of Rosario (AR)
- Administración Nacional de Laboratorios e Institutos de Salud (AR)
- Centro Científico Tecnológico - Bahía Blanca (AR)
- Instituto de Biología Molecular y Celular de Rosario (AR)
- Instituto Cardiovascular de Buenos Aires (AR)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fphar.2025.1570278
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- Ministerio de Ciencia, Tecnología e Innovación Productiva
- Agencia Nacional de Promoción de la Investigación, el Desarrollo Tecnológico y la Innovación