Comprehensive transcriptome assessment in PBMCs of post-COVID patients at a median follow-up of 28 months after a mild COVID infection reveals upregulation of JAK/STAT signaling and a prolonged immune response
Our findings highlight molecular changes compatible with a persistent immune response in PBMCs of post-COVID subjects at a median follow-up of 28 months after a mild infection, supporting the hypothesis that post-COVID is a chronic inflammatory condition. The upregulation of JAK/STAT signaling suggests a potential therapeutic target in post-COVID.
Authors
- René Kaden (ORCID: https://orcid.org/0000-0002-2111-9751)
- Joakim Klar (ORCID: https://orcid.org/0000-0003-4185-7409)
- Jens Schuster (ORCID: https://orcid.org/0000-0002-4383-9880)
- Jonas Bergquist (ORCID: https://orcid.org/0000-0002-4597-041X)
- Niklas Dahl (ORCID: https://orcid.org/0000-0002-8122-0800)
- Serena Fineschi
- Jesús Egido (ORCID: https://orcid.org/0000-0001-6321-2666)
Institutions
- Uppsala Monitoring Centre (SE)
- Uppsala University (SE)
- Uppsala University Hospital (SE)
- Science for Life Laboratory (SE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fimmu.2025.1589589
- Citations
- 3
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- Open Medicine Foundation
- Hjärnfonden
- Vetenskapsrådet
- Uppsala Universitet
- Science for Life Laboratory