Prognostic factors of invasive fungal infections in pediatric intensive care units and changes in treatment outcomes before and after the COVID-19 pandemic: a multicenter retrospective study
Agranulocytosis, hematologic malignancies, invasive mechanical ventilation, indwelling urinary catheter and blood transfusion are independent risk factors for adverse outcomes with invasive fungal infections in PICU, and identifying the pathogen can improve outcomes. Post-pandemic changes in fungal species and cumulative risk factors may have offset the potential benefits of reduced co-infection rates, leading to increased treatment failure rates. Therefore, it is necessary to optimize invasive procedure management and provide early coverage for emerging pathogens in high-risk children.
Authors
- Yibing Cheng (ORCID: https://orcid.org/0000-0003-3932-6334)
- Xiulan Lu (ORCID: https://orcid.org/0000-0002-8272-0903)
- Q. Zhang (ORCID: https://orcid.org/0000-0002-1016-7184)
- Ling Gong (ORCID: https://orcid.org/0000-0002-4173-7178)
- Lidan Cui (ORCID: https://orcid.org/0000-0002-5604-1843)
- Guoping Lü (ORCID: https://orcid.org/0000-0002-6815-4554)
- Jun Su
- Tian Li (ORCID: https://orcid.org/0000-0002-3488-1366)
- Liming He
- Li Huang (ORCID: https://orcid.org/0000-0002-1576-2265)
- Yuhui Du (ORCID: https://orcid.org/0000-0002-2036-5408)
Institutions
- Central South University (CN)
- Guangzhou Women and Children Medical Center (CN)
- Zhengzhou Children's Hospital (CN)
- Hunan Children's Hospital (CN)
- Children's Hospital of Fudan University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fmicb.2025.1605960
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fudan University
- National Key Research and Development Program of China