Enhanced resistance to Listeria infection in mice surviving sepsis: the role of lipid metabolism and myeloid cell reprogramming
Our findings suggest that sepsis survival induces lipid metabolic reprogramming in myeloid cells, contributing to enhanced immunity against intracellular pathogens. These insights reveal potential therapeutic targets within lipid metabolic pathways to improve host defense in sepsis survivors.
Authors
- Moses Lee (ORCID: https://orcid.org/0000-0003-1337-1065)
- Haruki Watanabe (ORCID: https://orcid.org/0000-0001-7837-086X)
- Tengfei Song (ORCID: https://orcid.org/0000-0002-6994-6609)
- Kwangmin Choi (ORCID: https://orcid.org/0000-0003-4671-962X)
- Myoungsun Son (ORCID: https://orcid.org/0000-0002-0655-3859)
- Barbara Sherry (ORCID: https://orcid.org/0000-0003-3119-1463)
- Yong-Rui Zou
- Betty Diamond (ORCID: https://orcid.org/0000-0002-3250-3804)
- Jaewoo Choi (ORCID: https://orcid.org/0000-0002-4673-0477)
- Junhwan Kim (ORCID: https://orcid.org/0000-0003-2155-5294)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Northwell Health (US)
- Oregon State University (US)
- Feinstein Institute for Medical Research (US)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fphar.2025.1588987
- Primary Topic
- Clinical Nutrition and Gastroenterology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health