Higher clozapine concentration-to-dose ratios at week 1 after initiation are associated with increased risk of clozapine-associated fever in Japanese patients with schizophrenia
Measuring blood clozapine levels on day 8 may help to better estimate the risk of clozapine-associated fever in patients with schizophrenia.
Authors
- Yoshifumi Onuma
- Mutsumi Sakata
- Hiroaki Tanifuji
- Naoki Horikawa (ORCID: https://orcid.org/0000-0001-8480-6420)
- Toshihiro Sato (ORCID: https://orcid.org/0000-0002-8807-2417)
- Masamitsu Maekawa (ORCID: https://orcid.org/0000-0001-6723-0298)
- Daisuke Kume (ORCID: https://orcid.org/0000-0003-4461-930X)
- Sota Ueno
- Kazuro Ikawa (ORCID: https://orcid.org/0000-0002-9349-4067)
- Hiroaki Tomita (ORCID: https://orcid.org/0000-0003-2628-880X)
- Nariyasu Mano (ORCID: https://orcid.org/0000-0003-1679-9024)
- Yuki Kikuchi (ORCID: https://orcid.org/0000-0002-1184-8918)
- Takeshi Toraiwa
- Hiroshi Komatsu (ORCID: https://orcid.org/0000-0002-7602-0281)
- Bunichiro Onodera
- Masato Ishihara
Institutions
- Hiroshima University (JP)
- Tohoku University (JP)
- Tohoku University Hospital (JP)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fpsyt.2025.1591568
- Citations
- 1
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47