Markers of T cell activation and exhaustion in plasma are associated with persistent symptoms up to 18 months following mild SARS-CoV-2 infection
Our study indicates a role for T cell activation/exhaustion in PCC following home isolated COVID-19 infection, with somewhat different patterns of sCD25, sTIM-3 and sLAG-3, but not in hospitalized COVID-19 patients where disease severity may be more important.
Authors
- Fan Zhou (ORCID: https://orcid.org/0000-0001-9918-3422)
- Pål Aukrust
- Thor Ueland (ORCID: https://orcid.org/0000-0001-5005-0784)
- Bjørn Blomberg (ORCID: https://orcid.org/0000-0001-5647-4297)
- Elisabeth Berg Fjelltveit (ORCID: https://orcid.org/0000-0001-8848-0325)
- Rebecca Jane Cox (ORCID: https://orcid.org/0000-0002-8341-4078)
- Kari Otterdal
- Annika E. Michelsen
- Tuva Børresdatter Dahl (ORCID: https://orcid.org/0000-0001-7818-9411)
- Nina Langeland (ORCID: https://orcid.org/0000-0003-0278-1616)
- Rebecca Elyanow (ORCID: https://orcid.org/0000-0001-8877-7188)
- Bente Evy Halvorsen
Institutions
- Oslo University Hospital (NO)
- University Hospital of North Norway (NO)
- University of Oslo (NO)
- Haukeland University Hospital (NO)
- Adaptive Biotechnologies (United States) (US)
- University of Bergen (NO)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fimmu.2025.1578208
- Citations
- 1
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Helse- og Omsorgsdepartementet
- Norges Forskningsråd