18F-NaF PET/CT identifies muscular and subcutaneous calcifications in both dermatomyositis- and systemic sclerosis-related calcinosis
<sup>18</sup>F-NaF PET/CT appears to be a sensitive method of detecting and characterizing calcinosis that provides both quantitative and qualitative data beyond what can be obtained by physical examination or CT alone. <sup>18</sup>F-NaF uptake occurs in muscle in both SSc and DM, suggesting the possibility that myositis may be driving calcinosis in a subset of patients with SSc.
Authors
- Ami A. Shah (ORCID: https://orcid.org/0000-0002-1139-2009)
- Caoilfhionn M Connolly (ORCID: https://orcid.org/0000-0002-1898-3530)
- Laura K. Hummers (ORCID: https://orcid.org/0000-0002-4864-4011)
- Lilja B. Sólnes (ORCID: https://orcid.org/0000-0002-2192-7425)
- Lisa Christopher-Stine
- Carrie Richardson (ORCID: https://orcid.org/0000-0002-2541-175X)
- Fredrick M. Wigley
- Mehrbod S. Javadi
Institutions
- Northwestern University (US)
- Johns Hopkins University (US)
Publication Details
- Journal
- Frontiers in Nuclear Medicine
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fnume.2025.1593825
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Jerome L. Greene Foundation
- National Institutes of Health