PLCH1 overexpression promotes breast cancer progression and predicts poor prognosis through the ERK1/2-EGR1 axis
PLCH1 was overexpressed in breast cancer and was associated with worse patient outcomes. Its role in promoting cell proliferation via the ERK1/2-EGR1 axis highlighted PLCH1 as a potential therapeutic target for breast cancer. These findings offer new insights into the molecular mechanisms underlying breast cancer progression and suggest promising avenues for targeted therapy development.
Authors
- Lei Song (ORCID: https://orcid.org/0000-0001-8975-5060)
- Fenge Jiang
- Congcong Wang (ORCID: https://orcid.org/0000-0003-3947-2569)
- Jing Li (ORCID: https://orcid.org/0000-0002-2326-8750)
- Ping Sun
- Jiannan Liu
Institutions
- Qingdao University (CN)
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Yuhuangding Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fonc.2025.1577114
- Citations
- 1
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.94