Development of novel spiro benzotriazole-based compounds with 1,3-dicarbonyl scaffolds via one-pot synthesis

In the present study, it was demonstrated that a new series of derivatives of 1,2-diphenyl-3H-spiro[benzo[d]pyrrolo[2,1-b]triazol-3,5′-pyrimidine (4) and 3,2′-indandione (6) were efficiently designed and synthesized via a novel, and less cumbersome one-pot methodology involving tri-component interactions among benzotriazole, 2-chloro-2-phenylacetophenone, and 1,3-dicarbonyl compounds in CH₂Cl₂ at room temperature 25°C for 3 hours without the use of a catalyst. The resulting compounds' structural configurations were verified with NMR, IR, EI-MS, and elemental analysis exhibiting good yield and high purity.