Chemoselective synthesis of imidazopyrimidine and triazolopyrimidine hybrids using cadmium incorporated fluoroapatite encapsulated γ-Fe2O3 magnetic nanocatalyst

In this report, a facile and efficient method for the synthesis of imidazopyrimidine and triazolopyrimidine derivatives using cadmium incorporated fluoroapatite encapsulated γ-Fe2O3 magnetic nanocatalyst is presented. To investigate the catalytic properties of γ-Fe2O3@FAp@Cd nanocatalyst, one-pot three-component reaction of malononitrile, aromatic aldehydes and 2-aminobenzimidazole or 3-amino-1,2,4-triazole was used. In this method imidazo[1,2-a]pyrimidine and 1,2,4-triazolopyrimidine derivatives were obtained in short reaction time (10-15 minutes) and excellent yield (85-95%). The catalyst was characterized by using analytical techniques such as FT-IR, XRD, SEM, EDX, VSM and used in five consecutive runs without notable decrease in its catalytic performance.