Biphasic contrast-enhanced [18F]PSMA-1007 PET/CT imaging to improve the detection of local relapse of prostate cancer
Given the aforementioned, highly specific unmet clinical need for a relatively small ratio of patients with prostate cancer undergoing PSMA imaging, our proposed acquisition protocol mandates a well-balanced preselection of patients. Under this premise, the study results demonstrated that the optimized acquisition protocol with biphasic contrast-enhanced [<sup>18</sup>F]PSMA-1007 PET/CT imaging improved the diagnostic performance for the detection of local PC recurrence in 67% of preselected patients.
Authors
- Julian Kirchner (ORCID: https://orcid.org/0000-0001-8224-3433)
- Jan Hausmann
- Matthias Boschheidgen (ORCID: https://orcid.org/0000-0002-1522-6374)
- Eduards Mamlins
- Tadashi Watabe (ORCID: https://orcid.org/0000-0001-8658-2395)
- Jan Philipp Radtke (ORCID: https://orcid.org/0000-0003-1009-6563)
- Jan Henke
- Gerald Antoch (ORCID: https://orcid.org/0000-0001-7834-3714)
- Jens Cardinale (ORCID: https://orcid.org/0000-0001-6558-966X)
- Mardjan Dabir
- Danny Jazmati (ORCID: https://orcid.org/0000-0003-1600-9926)
- Christina Antke
- Yuriko Mori (ORCID: https://orcid.org/0000-0001-5666-0559)
- Peter Albers (ORCID: https://orcid.org/0000-0002-1747-9615)
- Emil Novruzov (ORCID: https://orcid.org/0000-0003-1914-1332)
- Juliane Hörner‐Rieber (ORCID: https://orcid.org/0000-0003-3911-4438)
- Katalin Mattes‐György
- Günter Niegisch (ORCID: https://orcid.org/0000-0001-6929-8691)
- Lars Schimmöller (ORCID: https://orcid.org/0000-0001-7476-292X)
- Frederik Lars Giesel (ORCID: https://orcid.org/0000-0002-9669-5593)
Institutions
- Universitätsklinik Marien Hospital Herne (DE)
- Düsseldorf University Hospital (DE)
- Integrated Oncology (United States) (US)
- Heinrich Heine University Düsseldorf (DE)
- The University of Osaka (JP)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s13550-025-01252-4
- Citations
- 2
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 3.04