A novel strategy for identifying hepatotoxic constituents in traditional Chinese medicine using dose-normalized intracellular accumulation as a cytotoxicity indicator: a case study of Jinlingzi San
The findings suggest that dose-normalized intracellular accumulation serves as a reliable indicator for identifying hepatotoxic constituents in TCM. The observed reduction in intracellular accumulation of coptisine and berberine in the JLZS formulation compared to RC alone maybe reflect the scientific meaning of detoxicity by compatibility with FT and RC.
Authors
- Cuiting Wu
- Xiaoting Gu (ORCID: https://orcid.org/0000-0001-5832-2078)
- Keran Li (ORCID: https://orcid.org/0000-0003-1134-3490)
- Hanyang Wang (ORCID: https://orcid.org/0009-0002-2275-6987)
- Xin Di (ORCID: https://orcid.org/0000-0001-7196-0031)
Institutions
- Shenyang Pharmaceutical University (CN)
- Nankai University (CN)
- University of Manchester (GB)
- State Key Laboratory of Medicinal Chemical Biology
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fphar.2025.1585186
- Citations
- 1
- Primary Topic
- Drug-Induced Hepatotoxicity and Protection
- Type
- article
- Field-Weighted Citation Impact
- 1.56