Blood essential trace elements and Alzheimer’s disease biomarkers in midlife
This study identified statistically significant associations of serum molybdenum and cobalt levels with AD biomarkers, suggesting a potential protective effect of molybdenum against Aβ aggregation and exacerbation of pathologic tau phosphorylation by cobalt. These findings underscore the need for further longitudinal studies to explore the role of essential trace elements in AD pathogenesis.
Authors
- Roger L. Albin (ORCID: https://orcid.org/0000-0002-0629-608X)
- Brian P. Jackson (ORCID: https://orcid.org/0000-0003-2311-2972)
- Carrie A Karvonen-Gutierrez (ORCID: https://orcid.org/0000-0002-1950-5397)
- Henry L. Paulson (ORCID: https://orcid.org/0000-0002-0382-7535)
- David Morgan (ORCID: https://orcid.org/0000-0003-1224-7476)
- Sung Kyun Park (ORCID: https://orcid.org/0000-0001-9981-6250)
- Kelly M. Bakulski (ORCID: https://orcid.org/0000-0002-9605-6337)
- Xin Wang (ORCID: https://orcid.org/0000-0003-4776-6567)
Institutions
- Dartmouth College (US)
- Grand Rapids Community College (US)
- University of Michigan (US)
- VA Ann Arbor Healthcare System (US)
- Geriatric Research Education and Clinical Center (US)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fnagi.2025.1539749
- Citations
- 3
- Primary Topic
- Trace Elements in Health
- Type
- article
- Field-Weighted Citation Impact
- 3.36
Funders
- U.S. Department of Health and Human Services
- National Institutes of Health
- National Institute on Aging
- National Institute of Nursing Research
- National Institute of Environmental Health Sciences
- Office of Research on Women's Health