You are entitled to access the full text of this documentSynthesis and molecular docking studies of pyrazolo-oxazole derivatives as potential inhibitors of P. gingivalis heme-binding protein

The present paper elicits the studies on synthesis and potential pharmacological applications of pyrazolo-oxazole heterocyclic scaffolds. The synthesized compounds were characterized by different spectroanalytical tools including 1H NMR, 13C NMR, and FTIR techniques, followed by molecular docking-based biological interaction studies. Synthesized pyrazolo-oxazoles (8a–f) were docked against the heme-binding protein of P. gingivalis, an oral pathogen, responsible for a number of diseases. Among the synthesized heterocycles, compounds 8e and 8f showed better docking scores compared to the marketed drugs and thus are of great interest as lead compounds in developing treatment profiling to combat P. gingivalis-borne diseases.