Tertiary Amine‐Catalyzed Stereoretentive Multi‐Component Cascade Reaction of Carboxylic Acids: Facile Synthesis of Cyclic Ureas/Urethanes
Comprehensive Summary Herein, we developed a tertiary amine‐catalyzed stereoretentive multi‐component cascade reaction featuring an amidation/[4 + 1] annulation/decarboxylation/Curtius rearrangement/[2 + n ] annulation sequence. This metal‐free and step‐economic method provided a broad range of cyclic ureas/urethanes in green solvent under mild conditions without employing explosive and toxic reagents. Importantly, this reaction generated isocyanates in situ under catalytic conditions via a decarboxylation/Curtius rearrangement process of dioxazolones.
Authors
- Yi Hu (ORCID: https://orcid.org/0000-0002-6240-5391)
- Nengzhong Wang (ORCID: https://orcid.org/0000-0003-1690-7611)
- Zhong‐Yan Cao (ORCID: https://orcid.org/0000-0002-6858-5629)
- Dan Xiong (ORCID: https://orcid.org/0000-0003-0722-8668)
- Hui Qin Yao (ORCID: https://orcid.org/0000-0002-4450-8602)
- Nianyu Huang (ORCID: https://orcid.org/0000-0003-4483-160X)
- Yifei Cai (ORCID: https://orcid.org/0009-0000-9118-5298)
- Yanfei Liu (ORCID: https://orcid.org/0009-0000-9991-0087)
- Linxuan Li (ORCID: https://orcid.org/0000-0001-9836-1442)
Institutions
- China Three Gorges University (CN)
- Henan University (CN)
Publication Details
- Journal
- Chinese Journal of Chemistry
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1002/cjoc.70110
- Citations
- 5
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- National Natural Science Foundation of China
- Higher Education Discipline Innovation Project