Chitosan attenuates titanium dioxide nanoparticles induced hepatic and renal toxicities
Titanium dioxide nanoparticles (TiO<sub>2</sub> NPs) are extensively incorporated in numerous industrial products. Adult male Albino rats received oral TiO<sub>2</sub> NPs at a dose of 150 mg/kg body weight for 14 days exhibited both hepatic and renal toxicities manifested by disruption in serum hepatic and renal biomarkers, imbalance in oxidative-antioxidant system, up-regulation of mRNA expression of genes encode inflammation (IL-1β, TNF-α) and apoptosis (Caspase-3, BAX) with down-regulation of PCNA immune-staining density and histological modifications in hepatic and renal architecture. Carboxymethyl chitosan (5 mg/kg BW) significantly improved the harmful effects of nano-titanium particles highlighting its relevance in reducing TiO<sub>2</sub> NPs - induced hepatic and renal dysfunction.
Authors
- Ahmed A. Farghali (ORCID: https://orcid.org/0000-0002-9270-9855)
- Samah Lashen (ORCID: https://orcid.org/0000-0003-3633-8049)
- Mohamed Elmetwally
- Shaymaa Rezk
- Mohamed El‐Adl (ORCID: https://orcid.org/0000-0002-7696-6843)
- Amal Halawa (ORCID: https://orcid.org/0000-0003-2930-9477)
- Ehab Eldomany (ORCID: https://orcid.org/0000-0002-5135-0145)
- Nancy Shalaby
- Gehad E. Elshopakey (ORCID: https://orcid.org/0000-0003-2924-9670)
- Omar Elmetwally
Institutions
- Beni-Suef University (EG)
- Damietta University (EG)
- Mansoura University (EG)
Publication Details
- Journal
- Scientific Reports
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1038/s41598-025-01736-2
- Citations
- 3
- Primary Topic
- Nanoparticles: synthesis and applications
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Science and Technology Development Fund
- Mansoura University