In vitro Antimicrobial Activities of Temporin A and Apidaecin B Peptides Against Clinical Strains Isolated from Blood Culture

The increase in antimicrobial resistance poses a significant challenge in medicine, necessitating the exploration of novel antimicrobial agents. Temporin A and Apidaecin B, two naturally occurring antimicrobial peptides (AMPs), have garnered attention for their potent bactericidal properties. This study aimed to investigate the antimicrobial activities of Temporin A and Apidaecin B against clinical strains isolated from blood cultures and evaluate their potential as alternative therapeutic agents. A total of 12 <i>Escherichia coli</i>, 13 <i>Klebsiella pneumoniae</i>, 13 <i>Staphylococcus aureus</i>, and 12 <i>Staphylococcus epidermidis</i> strains were used for antimicrobial susceptibility tests. Antimicrobial activities were evaluated using the broth microdilution method. MIC values were detected as <3.9 for Temporin A against <i>S. aureus</i> and <i>S. epidermidis</i> and 7.81 for Apidaecin B against <i>E. coli</i>. The results underscore the potent antimicrobial properties of Temporin A against <i>S. aureus</i> and <i>S. epidermidis</i>, and Apidaecin B against <i>E. coli</i>. Further research is needed to optimize AMPs' stability, delivery mechanisms, and efficacy <i>in vivo</i>.