Design, Development, and Evaluation of Anti-diabetic Glibenclamide Microspheres using Natural Polymers by Ionotropic Gelation Method

Anti-diabetic drugs like glibenclamide (or glyburide) are used to manage the symptoms of type 2 diabetes. This action supports the pancreas in producing more insulin, thereby reducing high blood sugar. It is best when combined with a healthy diet and regular exercise. The drug can be combined with other diabetes treatments. When dealing with type 1 diabetes, it should not be used alone. It must be ingested orally. Using an ionic gelation process, a new SR system comprising Glibenclamidemicrospheres of alginate-chitosan was created. Its morphology and features of release were examined. The microspheres were simple to make, and as the amount of polymers increased, so did the microspheres' mean diameter. The concentration of chitosan and alginate had an impact on the microspheres' pore size. Microspheres are destroyed while stirring at high speeds above 200 rpm. When compared to traditional oral dosage forms, the microspheres demonstrated superior in-vivo activity and SR properties. Even when dealing with medications that don't dissolve well in water, using a drug entrapment method can be a valuable technique for creating complex, multi-particle drug delivery systems.