Comparative Study on Fast Dissolving Tablets of Piroxicam Prepared by Direct Compression and Sublimation Methods

Fast dissolving tablets (FDTs) are designed to disintegrate rapidly in the oral cavity without the need for water, enhancing patient compliance. Piroxicam, a non-steroidal anti-inflammatory drug (NSAID) with poor solubility, can be formulated as FDTs to improve its bioavailability and therapeutic efficacy. In this study, FDTs of piroxicam were prepared using direct compression and sublimation techniques. Various sublimating agents, such as camphor, was employed to create a porous structure, enhancing the dissolution rate. The prepared tablets were evaluated for post-compression parameters, including weight variation, friability, hardness, wetting time, disintegration time, and in vitro drug release. The results demonstrated that tablets formulated using sublimation exhibited faster disintegration and improved dissolution compared to those prepared by direct compression alone.