Exploring the publication gap in pediatric randomized clinical trials: completed vs. uncompleted pediatric clinical trials
Our study highlights significant challenges in pediatric RCTs, including high incompletion rates and delays in result reporting. Ethical, regulatory, and logistical barriers hinder progress, impacting evidence transparency. Strengthened regulatory oversight and enhanced compliance are essential to improve pediatric research outcomes and ensure timely dissemination of RCTs results.
Authors
- Kateřina Nebeská (ORCID: https://orcid.org/0000-0002-3902-8153)
- Radka Štěpánová (ORCID: https://orcid.org/0000-0002-7085-5499)
- Lenka Součková (ORCID: https://orcid.org/0000-0003-0028-4464)
- Regina Demlová (ORCID: https://orcid.org/0000-0002-3797-4453)
Institutions
- Masaryk University (CZ)
- University Hospital Brno (CZ)
- International Clinical Research Center, St. Anne's University Hospital Brno (CZ)
- St. Anne's University Hospital Brno (CZ)
- European Clinical Research Infrastructure Network (FR)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fmed.2025.1590125
- Primary Topic
- Pharmaceutical studies and practices
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministerstvo Školství, Mládeže a Tělovýchovy