Compositional and functional gut microbiota alterations in mild cognitive impairment: links to Alzheimer’s disease pathology
Our findings challenge genus-level microbiome analyses, revealing species-specific modulators of AD pathology. This study highlights gut microbial activity as a potential therapeutic target to mitigate cognitive decline and neurodegeneration.
Authors
- Yi‐Chien Liu (ORCID: https://orcid.org/0000-0003-2579-740X)
- Yen‐Ling Chiu (ORCID: https://orcid.org/0000-0003-4504-5571)
- Seong‐Ho Koh (ORCID: https://orcid.org/0000-0001-5419-5761)
- Kang-Chen Fan (ORCID: https://orcid.org/0009-0000-1931-0226)
- Chen-Ching Lin (ORCID: https://orcid.org/0000-0002-7831-7855)
- Yi‐Fang Chuang (ORCID: https://orcid.org/0000-0002-5421-9855)
Institutions
- National Yang Ming Chiao Tung University (TW)
- National Taiwan University (TW)
- Far Eastern Memorial Hospital (TW)
- Hanyang University Guri Hospital (KR)
- Cardinal Tien Hospital (TW)
- Anyang University (KR)
- Yuan Ze University (TW)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s13195-025-01769-9
- Citations
- 15
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 17.46
Funders
- Shanghai Educational Development Foundation
- Far Eastern Memorial Hospital
- National Science and Technology Council