Hippocampal subfields: volume, neuropathological vulnerability and cognitive decline in Alzheimer’s and Parkinson’s disease
Even though p-tau was the strongest predictor of hippocampal subfield atrophy, AD-pathology (p-tau and amyloid-β) only partially accounted for volumetric differences in hippocampal subfields, highlighting the significance of other pathologies or mechanisms. The increased sensitivity of subicular and entorhinal cortical atrophy compared to total hippocampal atrophy highlights the potential clinical value of incorporating hippocampal subfield atrophy in monitoring disease progression.
Authors
- Irene Frigerio (ORCID: https://orcid.org/0000-0003-1780-2862)
- Laura E. Jonkman (ORCID: https://orcid.org/0000-0003-1479-3649)
- Niels Reijner
- Wilma D. J. van de Berg (ORCID: https://orcid.org/0000-0002-6175-5357)
- Maud M.A. Bouwman (ORCID: https://orcid.org/0000-0002-9481-0332)
- Chen‐Pei Lin (ORCID: https://orcid.org/0000-0002-3273-4223)
Institutions
- Amsterdam Neuroscience (NL)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s13195-025-01768-w
- Citations
- 5
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.82
Funders
- National Alcohol Beverage Control Association
- Alzheimer Nederland