Highly Emissive Luminophores for Direct Chemiluminescence Detection
Direct chemiluminescence (CL) detection requires a proper luminophore to emit light through nonenzymatic activation. Herein, we synthesized a new class of 3-aminophthalhydrazide-type luminophores (LM-1-LM-13) with intensive CL emission. A typical analogue LM-5 was studied in detail, which exhibits greatly improved CL properties and enhanced storage stability compared to the widely used luminophore <i>N</i>-(4-aminobutyl)-<i>N</i>-ethylisoluminol (ABEI). The result of magnetic bead-based CL detection reveals that LM-5 holds great potential to become a next-generation luminophore in biosensing applications.
Authors
- Chun Cai (ORCID: https://orcid.org/0000-0002-5755-9361)
- Tao Deng (ORCID: https://orcid.org/0000-0002-3965-9553)
- Sha Wei (ORCID: https://orcid.org/0000-0002-7357-9346)
- Xinxin Huang
- Ying Ma (ORCID: https://orcid.org/0000-0003-2204-0663)
- Fang Liu (ORCID: https://orcid.org/0000-0003-1707-5183)
- Qilin Wang (ORCID: https://orcid.org/0000-0002-5744-2331)
- Liying Huang
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Nanjing University of Science and Technology (CN)
- Artemis (United States) (US)
- Institute of Chemical Engineering (BG)
- South China University of Technology (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1021/acs.orglett.5c01057
- Citations
- 2
- Primary Topic
- Advanced biosensing and bioanalysis techniques
- Type
- article
- Field-Weighted Citation Impact
- 1.61