Complexation and Solubility Enhancement of BCS Class II Drug using Cyclodextrins

Complexation can improve the solubility of drug substances by forming a complex between the drug substance and a complexing agent. Complexing agents are typically small molecules that have the ability to form stable complexes with the drug substance through non-covalent interactions such as hydrogen bonding, Van der Waals forces, or electrostatic interactions. The formation of a complex between the drug substance and the complexing agent can increase the solubility of the drug substance by improving its dispersibility in the solvent. This can occur through several mechanisms, such as increasing the polarity of the solvent system, reducing the crystal lattice energy of the drug substance, or decreasing the intermolecular forces between drug molecules. Common complexing agents used in pharmaceutical formulations include cyclodextrins, polymeric compounds such as polyvinylpyrrolidone (PVP), and amino acids such as arginine and lysine. In the present study solubilization and release properties of Celecoxib was tried to enhance by complexation with the βCD & HPβCD.