Baseline profile peripheral Tfh cells predict immune-related adverse events in immune checkpoint inhibitor therapy of gastrointestinal cancer
This study demonstrates that high-dimensional immune profiling can uncover novel blood-based immune signatures associated with the risk and mechanism of severe irAEs are effective biomarkers for predicting irAEs at both baseline and early stages of ICIs treatment.
Authors
- Ruiling Feng (ORCID: https://orcid.org/0000-0003-1465-3259)
- Qinghong Liu
- Ruoyi Wang (ORCID: https://orcid.org/0009-0002-7995-0692)
- Bo Huang (ORCID: https://orcid.org/0000-0001-6196-5373)
- Naidi Wang
- Xiaoyan Xing
- Yipeng Han
- Zhening Zhang (ORCID: https://orcid.org/0000-0001-8006-524X)
- Jing He (ORCID: https://orcid.org/0000-0001-6870-3640)
- Yudong Liu (ORCID: https://orcid.org/0000-0002-5153-3400)
- Hao Li (ORCID: https://orcid.org/0000-0002-7890-6772)
- Yifan Wang (ORCID: https://orcid.org/0000-0002-2512-3774)
- Cheng Zhang (ORCID: https://orcid.org/0000-0003-3647-7241)
- Xue Li (ORCID: https://orcid.org/0000-0003-0342-8013)
- Zhi Peng (ORCID: https://orcid.org/0000-0003-4063-9813)
- Tong Xie
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Peking University Cancer Hospital (CN)
- Peking University People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-29
- DOI
- https://doi.org/10.3389/fimmu.2025.1559275
- Citations
- 1
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Natural Science Foundation of China
- Beijing Nova Program