Analysis of Mediator Variables of Type 2 Diabetes and Calcific Aortic Valve Disease

本研究探讨在T2DM与CAVD的关系中体重指数、高血压、慢性肾脏病、甘油三酯葡萄糖指数、总胆固醇/高密度脂蛋白比值、中性粒细胞/淋巴细胞比值的中介作用。纳入2018年1月至2022年12月青岛大学附属医院心脏大血管外科和健康体检中心的患者数据，采用因果中介效应分析方法，探讨T2DM与CAVD的中介变量。共纳入3979名参与者，CAVD组1925人，非CAVD组2054人。高血压、甘油三酯葡萄糖指数、总胆固醇/高密度脂蛋白比值、中性粒细胞/淋巴细胞比值、慢性肾脏病的中介效应分别为0.114、0.042、0.029、0.015、0.006 (P均This study aims to investigate the mediating effects of body mass index, hypertension, chronic kidney disease, triglyceride-glucose index, total cholesterol/high-density lipoprotein ratio, and neutrophil-to-lymphocyte ratio in the relationship between type 2 diabetes mellitus (T2DM) and calcific aortic valve disease (CAVD). Data from patients at the Department of Cardiothoracic Surgery and the Health Examination Center of Qingdao University Affiliated Hospital between January 2018 and December 2022 were included. Causal mediation analysis was used to explore the mediating variables in the association between T2DM and CAVD. A total of 3979 participants were included, with 1925 in the CAVD group and 2054 in the non-CAVD group. The mediating effects of hypertension, triglyceride-glucose index, total cholesterol/high-density lipoprotein ratio, neutrophil-to-lymphocyte ratio, and chronic kidney disease were 0.114, 0.042, 0.029, 0.015, and 0.006, respectively (all P < 0.001). Hypertension had the largest mediating effect, followed by the triglyceride-glucose index. Based on these findings, intensive management of blood pressure, blood glucose, and blood lipids in diabetic patients may reduce the risk of CAVD.