Effects of the Ketogenic Diet on Neutrophilic Asthma

支气管哮喘作为一种常见慢性呼吸道疾病，其发病机制复杂，尤其是中性粒细胞型哮喘，对吸入性糖皮质激素反应差，治疗难度大。当前研究对中性粒细胞型哮喘的病理生理机制及其有效治疗手段尚存在不足。本综述旨在探讨生酮饮食对中性粒细胞型哮喘的潜在影响，通过分析生酮饮食对中性粒细胞募集与活化、免疫反应调节及肠道菌群改变等方面的影响，揭示其可能的作用机制。综合现有研究，生酮饮食在中性粒细胞型哮喘的治疗中展现出了良好的应用前景，为哮喘治疗策略的优化提供了参考价值。As a common chronic respiratory disease, bronchial asthma has a complex pathogenesis, especially neutrophilic asthma, which has a poor response to inhaled glucocorticoids and is difficult to treat. The current research on the pathophysiological mechanism of neutrophilic asthma and its effective treatment methods is still insufficient. The aim of this review was to explore the potential effects of the ketogenic diet on neutrophilic asthma, and to reveal its possible mechanism of action by analyzing the effects of the ketogenic diet on neutrophil recruitment and activation, immune response regulation, and changes in gut microbiota. Based on the existing research, the ketogenic diet has shown a good potential for application in the treatment of neutrophilic asthma, which provides a reference value for the optimization of asthma treatment strategies.