Longitudinal Symptom Analysis of COVID-19 Survivors and Post-COVID Syndrome Patients

<b>Background/Objectives:</b> The present study aimed to analyze changes in symptom intensity during the recovery period of COVID-19 survivors and patients with post-COVID syndrome. <b>Methods:</b> Initially, we described a new remote patient monitoring system to track the intensity of specific symptoms in individuals' home environments. Remote patient monitoring (RPM) was implemented over 15 days in a cohort of 133 individuals aged 20 to 78 years, divided into four groups: mild (MG, n = 40), Hospital Discharge Without Invasive Mechanical Ventilation (WIMV, n = 40), Hospital Discharge With Invasive Mechanical Ventilation (IMV, n = 13), and reinfected (RG, n = 40). <b>Results:</b> The most prevalent symptoms reported across all groups, based on average intensity, were shortness of breath, fatigue, cough, headache, and body pain. The WIMV group exhibited the highest average intensities in six symptoms (<i>p</i> < 0.01), while the IMV group reported the highest averages in four symptoms (<i>p</i> < 0.05). Fatigue was the symptom with the highest overall intensity, followed by memory lapses. The hospitalized groups demonstrated the highest intensities and most persistent symptoms (<i>p</i> < 0.05). Blood pressure was significantly higher in the MG group compared to the RG group (<i>p</i> < 0.0001), although all values remained within the normal range. <b>Conclusions:</b> These results provide novel insights, revealing distinct differences in the symptom profiles among the studied groups. These findings hold significant implications for developing more personalized care strategies and informing future pandemic preparedness and response efforts.